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Do not apply the Estradiol Transdermal System to the breasts (2.5) Dosage Forms and Strengths • Transdermal system 0.025 mg per day, 0.0375 mg per day, 0.05 mg per day, 0.06 mg per day, 0.075 mg per day and 0.1 mg per day (3) Contraindications • Undiagnosed abnormal genital bleeding (4, 5.2) • Breast cancer or a history of breast cancer (4, 5.2) • Estrogen-dependent neoplasia (4, 5.2) • Active DVT, PE or a history of these conditions (4, 5.1) • Active arterial thromboembolic disease (for example, stroke or MI), or a history of these conditions (4, 5.1) • Known anaphylactic reaction, or angioedema, or hypersensitivity to Estradiol Transdermal System (4) • Hepatic impairment or disease (4, 5.10) • Protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders (4) Warnings and Precautions Adverse Reactions/Side Effects The most common adverse reactions (≥10 percent) with the Estradiol Transdermal System are: breast pain, upper respiratory tract infections, headaches, abdominal pain, pain, and edema